6JFH coupling in the conformational analysis of fluorinated drugs

Cassia Chiari – @CassiaChiari

The forefront treatment of onychomycosis is topical therapy, however, there is a gap of knowledge on the conformational behaviour of these drugs in solution. Therefore, the present work aimed to investigate and compare efinaconazole (topical therapy) and voriconazole (oral therapy) using NMR and theoretical calculations in CDCl3, DMSO-d6 and D2O.