NORD-NOESY modified NMR of Deep Eutectic Solvents

Kelsey Marr – @kelsey_marr

"Why are my NOESYs give bad build up curves??" For us it was radiation damping! Checkout my work: #GlobalnmrOC2024 @ajerschow @global_nmr pic.twitter.com/WWkSj2KkIf

— Kelsey Marr (@kelsey_marr) July 17, 2024

Deep eutectic solvents (DES) are low-cost, no-waste mixtures made of hydrogen bond acceptors (HBA) and hydrogen bond donors (HBD). One of the most common DES is ethaline, 1:2 choline chloride to ethylene glycol. The aim of this work is to fully elucidate the hydrogen bond network structure by 2D NMR, specifically through Nuclear Overhauser spectroscopy (NOESY). Previous attempts for ethaline have been hindered by multiple effects, one of the most prominent being radiation dampening. We have successfully utilized a NO Radiation Dampening (NORD) pulse sequence modification to the NOESY sequence and obtained build up curves of NOE and of chemical exchange.