Manasi Ghosh – @ManasiGhosh20
The atomic-level structure and dynamics of two enantiomers, ofloxacin and levofloxacin, were studied through various solid-state NMR techniques. The investigation involved measuring the principal components of the chemical shift anisotropy (CSA) tensor, spatial proximity of 1H and 13C nuclei, and site-specific 13C spin-lattice relaxation time. Additionally, the correlation between biological activity and nuclear spin dynamics was established through these investigations. NMR crystallography approaches played a crucial role in the in-depth chemical analysis of antibiotics, which is essential for advanced drug design.
Leave a Reply