Conformational Plasticity of Parallel G-quadruplex – Implications on Duplex-Quadruplex Motifs

Rajesh Kumar Reddy Sannapureddi – @RR_Sannapureddi

#GlobalnmrTC2023
Insights in to Parallel G-Quadruplex structure and flexibility. Differential dynamics across G-tetrads, 5' and 3'-ends. Implications for Duplex-Quadruplex motifs.
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— Rajesh Sannapureddi (@RR_Sannapureddi) July 20, 2023

Parallel G-quadruplexes formed by guanine rich sequences are ubiquitously formed in promoter, telomere regions. Structural and dynamic features associated with them is presented in details from structure survey, solution state NMR studies and MD simulations. Impact of covalently attached duplex on parallel quadruplex discerned from NMR studies are presented.