Identify the initial pinning sites of tau to seeding-competent fibrils and the role of structural water

Chung-Ta Han

NMR can definitely play a big role in unveiling the secret of Alzheimer's disease! We utilize solution NMR to understand which part of the tau protein initiates its pinning to a tau amyloid fibril.#GlobalnmrOC2024 @songihanlab #AlzheimersAwarenessMonth pic.twitter.com/SXfOF8hXiu

— Chung-ta Han (@chungtahan) July 17, 2024

We interrogate the key residue(s) that initiate the pinning of soluble Tau onto existing fibril active ends by tracking the time evolution of 1H-15N correlation spectra along the fibril seeding process of a tau construct composed of 19 amino acids.