Quantitative NMR of chloride by an accurate internal standard approach

Jared Scott Wood – @jaredscottwood

Quantitative NMR of chloride by an accurate internal standard approach #GlobalnmrTC2022 pic.twitter.com/IgMMwfHcHn

— Jared Wood (@nmrpercussion) August 3, 2022

Quantitative analysis of heteroatoms in small molecule active pharmaceutical ingredients is crucial for the development of modern therapeutics. Here we present a robust and generally applicable 35Cl solution qNMR method to assay the level of chloride in pharmaceutical compounds.