Structural Insights into gp120 Glycan Recognition by 2G12 Antibody: A Paramagnetic NMR approach

Mayra Paola Oquist Phillips – @oquist_paola

Thrilled to present my short video at the #GlobalnmrOC2024 congress! A big thank you to our amazing collaborators @_fjrm, @javiRamSor & #AdrianSilva from @cicCartuja.#NMR #nmrchat #glycotime @global_nmr @AngelesCanale11 @madNMRgroup @UCM_OrgChem https://t.co/r0z4vq4sm6

— Paola Oquist (@oquist_paola) July 17, 2024

Glycoprotein 120 (gp120) shields the HIV virus using high mannose glycans, which are difficult to analyze structurally due to their high isochronicity causing NMR signal collapse. Novel NMR methods, including paramagnetic probes, now enable detailed study of gp120 and its interaction with the neutralizing antibody 2G12.