Alexander Barnes – @MagnetXander
I have a dream. I dream of hundreds and thousands of 100 Tesla Pulsed Dynamic Nuclear Polarization NMR spectrometers sitting on bench-tops and equipped with magic angle spinning spheres spinning a million times a second. To make this dream a reality, talented, ambitious, and dedicated scientists at the ETH Zurich are developing new magnets, microwave technology, and MAS instrumentation. Let me tell you about it.
Julie Maibøll Buhl – @ll_buhl95024
The environment of biomolecular condensates, formed by LLPS, can be investigated using determined partitioning coefficients from a wide range of molecules. The time-zero 1H-13C HSQC was proposed and tested on a model system, where repetitions of the pulse sequence allows for correction of signal attenuation leading to precise quantification.
Valentina Sobornova – @VSobornova7121
https://twitter.com/VSobornova7121/status/1681239368332132353?s=20
The effect of mefenamic acid on the physicochemical and sorption properties of aerogel was studied. 1H and 13C MAS, T1-T2 RRCOSY and 1H-1H NOESY NMR experiments were carried out to study the conformational state of mefenamic acid and its effect on the aerogel structure. The results show that the group fraction of conformer groups of mefenamic acid changes by 53% in the presence of aerogel.
Plamen Chorbadzhiev – @NMR_P_Ch_0359
Craft beer have been gaining popularity for the past years, yet their chemical profile is poorly studied. 1H NMR metabolomics is used to determine their main components, as well as to distinguish four styles of beer – lager, pale ale, Indian pale ale and stout.
Konstantin Belov – @SCFsci
Determination of the predominant conformation of small molecules of drug in solution is one of the fundamental tasks of modern pharmaceutical and physical chemistry. Our research group “Fluid State NMR” has proposed a number of technical and methodological ways to solve this problem in the supercritical fluid environment.
Kelsey Marr – @kelsey_marr
Magnesium is the most abundant divalent cation in the cell and essential to nearly every biochemical reaction involving adenosine triphosphate and its lower energy counterpart, adenosine diphosphate. This work has focused on using 31P and 1H NMR as a tool to understand chemical and molecular interactions between ADP and Mg for evidence of nucleotide aggregation either by self-association or influenced by cations.
Covadonga Lucas-Torres – @covalucas
POPs deserve a particular attention among the chemical pollutants constituting the human exposome, since due to their lipophilic properties and resistance regarding the xenobiotic metabolism, they can bio-accumulate for long periods of time in adipose tissues. This innovative untargeted metabolomics study aims investigating the low-dose and chronic internal exposure to a cocktail of POPs, on multiple tissues known to accumulate these lipophilic compounds.
Jiaqi Lu – @Jiaqi_Lu22
Our research has unveiled the existence of hidden phosphate clusters, eluding spectroscopic detection. By manipulating solution conditions, notably pH, we expose their intricate behavior. Employing the power of chemical exchange saturation transfer, we discover new spectroscopic features, and provide further evidence for clustering. These results are important for studying phosphate function in the physiological environment.
Shadan Geshani – @ShGeshani
Vancomycin is a clinically-used glycopeptide antibiotic, used for the treatment of severe infections. Vancomycin kills bacteria by targeting cell wall precursors in the bacterial membrane, however, resistance mechanisms against this antibiotic have been widely known in pathogenic species. Molecular details of vancomycin’s action could only be studied in the absence of membranes. A better understanding of the molecular mechanism of vancomycin by ssNMR at atomic level will help to overcome this problem.
Sofia Mariasina and Kamil Aysin – @SMariasina and @Aysin_Kamil
We study new chromosomal rearrangements possibly causing lung cancer. We take human cell lines and reproduce in vitro mutations found in the tumors of cancer patients and test them for malignant transformation. Since cancer cells metabolism differs significantly from normal one we can use NMR metabolomics to detect malignancy
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