The contractile sheath of Klebsiella pneumoniae’s Type VI Secretion System as a target for Virulence Blockers

Izabelle Oyamada dos Santos – @izaoyamada

Klebsiella pneumoniae is a Gram-negative bacterium known to cause hypervirulent and multidrug-resistant infections. The T6SS is a virulence mechanism that facilitates the secretion of effector proteins into target cells. VipA makes up the contractile sheath of this system. We optimized the conditions for determining the structure of VipA_CTD using NMR and performed fragment screening.