Understanding Dynamic Exchange using Variable Field NMR

Jean-Paul Heeb – @jpheeb

Variable Temperature #NMR is a great tool to study exchange but sometimes it is not good enough. In this work, @Buttsresearchgp, @ClaydenGroup and I show the next step forward following some old work from the @mancNMR geniuses.@BCS_CDT @BristolChem
#GlobalnmrTC2023 #NMRchat pic.twitter.com/TN7VYjc7fi

— Jean-Paul Heeb (@jpheeb) July 19, 2023

We have been able to reliably chemical shift scale NMR spectra from 500 to 50 MHz for small molecule systems undergoing dynamic exchange (atropisomers). Using this, we can observe coalescence at lower temperatures, plot Eyring graphs and estimate activation parameters with smaller uncertainties than VTNMR alone.