Hyperpolarization NMR
Metal-Ion Dynamic Nuclear Polarization NMR – A Novel Tool for Studying MOF-based Materials
Ilia B. Moroz - @IliaMoroz92
Host-guest interactions in MOFs are key to their performance in various applications. Solid-state NMR can probe these interactions, however, with limited sensitivity. I will demonstrate how endogenous metal-ion DNP can tackle this challenge, keeping MOF pores empty for guests, and discuss the effect of MOFs mobility and molecular O2 on the DNP efficacy.
Towards Pulsed DNP at 100 Tesla
Alexander Barnes - @MagnetXander
I have a dream. I dream of hundreds and thousands of 100 Tesla Pulsed Dynamic Nuclear Polarization NMR spectrometers sitting on bench-tops and equipped with magic angle spinning spheres spinning a million times a second. To make this dream a reality, talented, ambitious, and dedicated scientists at the ETH Zurich are developing new magnets, microwave technology, and MAS instrumentation. Let me tell you about it.
Dynamic nuclear polarization by two-pulse phase modulation
Venkata SubbaRao Redrouthu - @rvsubbarao
The coherent transfer of electron spin polarization to nuclei by means of a microwave pulse sequence is a promising new approach to enhancing the sensitivity of solid-state nuclear magnetic resonance (NMR). The development of pulse sequences for dynamic nuclear polarization (DNP) of bulk nuclei is far from complete, as is the understanding of what makes a good DNP sequence. In this context, we introduce a new sequence, termed Two-Pulse Phase Modulation (TPPM) DNP. We provide a general theoretical description for electron–proton polarization transfer by periodic DNP pulse sequences and find it in excellent agreement with numerical simulations.
DNP and Electron Paramagnetic Resonance (EPR) of Substitutional Nitrogen in Diamond at 7 and 14 T
Amit Israelstam, Eyal Laster, Orit Nir-Arad - @DNP_EPR
EPR and DNP-enhanced 13C NMR measurements on our home-built dual DNP/EPR spectrometer reveal unknown properties of substitutional nitrogen centers in diamond, which are used to interpret their DNP spectra. High field EPR data is shown indispensable for both diamond defect spin system characterization and DNP spectral analysis.
Design and performances of a Tabletop DNP Polarizer : Towards recyclable hyperpolarization
Charlotte Bocquelet - @Charlotte_Boc
Dissolution Dynamic Nuclear Polarization provides a 10'000-fold gain in sensitivity but is incompatible with multi-scan experiments. Our ambition is to turn d-DNP into a new version widely compatible with NMR spectroscopy by replenishing hyperpolarization with a compact instrumentation for melt-DNP. Here I present the performances of the 1T polarizer using water-soluble radicals and porous matrices.
DNP in Multiradicals with Sub-Nanometer Electron-Electron Distances
Raj Chaklashiya - @RajChaklashiya
Multielectron Dynamic Nuclear Polarization (ME-DNP) is proposed to be a promising mechanism to achieve NMR signal enhancements due to its low microwave power requirement and scalability to high magnetic field. Here we explore experimentally and theoretically how to achieve this using a designed multielectron geometry of spatially proximal narrow-line radicals.
Solid-state NMR revealed peculiar phosphonate in velvet worm slime
Alexandre Poulhazan - @AlexPoulhazan
Velvet worms are fascinating animals that have a peculiar way to hunt. They eject a translucent liquid, the slime, that quickly forms sticky fibers trapping their preys. In addition to exciting recyclability of this natural glue, this slime has been characterized here by MAS-DNP and NMR, detecting unprecedented phosphonate-rich molecules.
Improving XiX DNP with optimal control
Shebha Anandhi Jegadeesan - @AnandhiJ61993
We use quantum optimal control algorithm to improve XiX DNP. The optimized DNP sequences with initial pulse lengths of 12 and 20 ns gave enhancements 2.4 and 1.6 times greater than XiX DNP, respectively. The challenges and anomaly between the numerical simulations and experiments will be addressed in the poster
NMRduino: a modular, open-source sub-MHz MR platform
Michael Tayler - @NMRduino / @mcdtayler
NMRduino is a sub-MHz NMR spectrometer designed unsparingly for minimum complexity, providing low-entry-barrier-NMR for beginners and those who wish to build custom hardware. Utility ranges from exploration of basic NMR concepts such as phase cycling and coherence selection to advanced experimental control including low-frequency, low-field parahydrogen-induced hyperpolarization and spin decoupling.
Off-the-Shelf Gd(NO3)3 as an Efficient High-Spin Metal Ion Polarizing Agent for Magic Angle Spinning Dynamic Nuclear Polarisation
Daniel Cheney - @DanielCheney14
Paramagnetic metal ion complexes have been demonstrated as an alternative to traditionally-used biradical polarising agents for DNP, which are typically not commercially available. Based on this, we have introduced Gd(NO3)3 as an easily accessible and inexpensive “off-the-shelf” polarising agent, providing significant sensitivity enhancements for 13C and 15N.
Imaging and spectroscopic applications in cancer research
Madhu Basetti - @mbasetti
We are an imaging core group working in cancer research with preclinical imaging modalities for early detection and prognosis of cancer.