Videos
NMR Strategies for Examining Interactions with Nanoparticles
During the 77th session of the Global NMR Discussion Meetings held on December 19st, 2023 via Zoom, Prof. Leah B. Casabianca from Clemson University, United States, gave a talk on the topic "NMR Strategies for Examining Interactions Between Small Molecules and Nanoparticle Surfaces". The recording serves as a tutorial.
Abstract:
Interactions between small molecules and the surface of nanoparticles are important in a variety of fields, from drug delivery to the fate of nanoparticles in the environment. In this talk, I will discuss several NMR techniques that can be used to gain structural and dynamic information about these interactions, with a focus on saturation-transfer difference (STD)-NMR.
Prof. Leah Casabianca's research group website: https://chemistry.sites.clemson.edu/c...
Chemical Exchange Saturation Transfer (CEST) MRI
During the 62nd session of the Global NMR Discussion Meetings held on February 21st, 2023 via Zoom, Prof. Elena Vinogradov gave a talk on the topic "Chemical Exchange Saturation Transfer (CEST) MRI: from basic principles to potential clinical applications". The recording serves as a tutorial.
Abstract:
Novel MRI methods are focusing on imaging events and structures at the molecular level. One of the methods gaining popularity is Chemical Exchange Saturation Transfer (CEST). Here we will discuss basic physical principles of this approach, followed by potential applications and challenges associated with the translation to in-vivo and human imaging.
Prof. Elena Vinogradov is an associate Professor at UT Southwestern Medical Center in Dallas, Texas.
Using Deep Learning to Transform and Analyse NMR Data
During the 55th session of the Global NMR Discussion Meetings held on November 1st, 2022 via Zoom, Prof. Flemming Hansen from University College London, gave a talk on the topic "Using Deep Learning to Transform and Analyse NMR Data". The recording serves as a tutorial.
It will be shown how deep neural networks (DNNs) can be trained for reconstruction of sparsely sampled NMR spectra and for virtual homonuclear decoupling. Another area covered in the talk will be autonomous analysis of chemical exchange saturation transfer (CEST) data, where the trained DNN accurately predicts both the chemical shifts and the uncertainties associated with these.
Speaker's biography:
1997-2003: BSc+MSc, Chemistry + Physics, University of Copenhagen
2003-2005: PhD in Biophysical Chemistry (Prof. Jens Led) , University of Copenhagen
2005-2010: Postdoctoral fellow (Prof Lewis E. Kay), University of Toronto
2010-present: PI, University College London. Full Professor since 2017.
Follow Prof. Hansen's work here:
Twitter: https://twitter.com/dflemminghansen?l...
Google scholar: https://scholar.google.com/citations?...
Website: https://www.ucl.ac.uk/hansen-lab/flem...
Structure & Thermodynamics of Sorption Equilibria using NMR
During the 46th session of the Global NMR Discussion Meetings held on April 5, 2022 via Zoom, Prof. Vincenzo Venditti from Iowa State University gave a talk on the topic "Solution NMR methods for structural and thermodynamic investigation of sorption equilibria". The recording serves as a tutorial.
Abstract:
Nanoparticles are highly tunable materials that owe some of their unique properties to the ability to efficiently and selectively adsorb their target ligands. In this tutorial we will discuss the use of DEST, relaxation dispersion, and R1 experiments for investigating structure, kinetics, and thermodynamics of sorption with atomic resolution.
Venditti group website: https://group.chem.iastate.edu/Venditti/
Google Scholar: https://scholar.google.com/citations?...
Speaker's biography: Vincenzo Venditti received a Ph.D. from the University of Siena in 2009 for his work with Neri Niccolai and Sam Butcher on the surface accessibility of biopolymers. From 2009 to 2014 he was a Postdoctoral Fellow at the National Institutes of Health in the group of Marius Clore where he specialized in biomolecular NMR techniques for the investigation of protein structure, dynamics and interactions. Vincenzo joined the Department of Chemistry at ISU in January 2015.
Two-dimensional lineshape analysis of biomolecular interactions
In session 30 held on 22nd June 2021, Dr. Chris Waudby gave a talk on Two-dimensional lineshape analysis of biomolecular interactions, via Zoom. The video was recorded live during the presentation and serves as an educative lecture. For more information on TITAN 2D NMR lineshape analysis, see https://www.nmr-titan.com.
Bio: Dr. Chris Waudby
2000-2004: BA MSci, Natural Sciences (Chemistry), University of Cambridge, UK
2004-2009: PhD, Chemistry, Prof. Chris Dobson, University of Cambridge, UK
2010-present: Postdoc, Prof. John Christodoulou, University College London, UK
Follow Dr. Waubdy: Google scholar: https://scholar.google.com/citations?...
Website: https://www.ucl.ac.uk/biosciences/dep...
Twitter: https://twitter.com/chris_waudby
Abstract: NMR titration experiments are a rich source of structural, mechanistic, thermodynamic and kinetic information on biomolecular interactions, which can be extracted through the quantitative analysis of resonance lineshapes in 2D spectra. We will review the basic principles of chemical exchange in one-dimensional NMR, and then discuss a range of surprising and useful effects that can arise when these principles are applied to multi-dimensional experiments. We will touch on the optimal design of titration experiments and selection of pulse programs, and give a tutorial on data analysis using the TITAN software package.
References:
https://www.nature.com/articles/srep2...