Videos
NMR Metabolomics in Drug Discovery and Disease Diagnosis
During the 82nd session of the Global NMR Discussion Meetings held on March 12th, 2024 via Zoom, Prof. Robert Powers from the University of Nebraska-Lincoln, United States, gave a talk on the topic "The Application of NMR Metabolomics to Drug Discovery and Disease Diagnosis". The recording serves as a tutorial.
Abstract: NMR-based metabolomics has benefited a variety of fields including drug discovery and disease diagnosis. Metabolomics is technically very challenging and requires expertise in a diversity of scientific areas. In this regard, this tutorial will discuss best practices for sample preparation and handling, data collection and analysis, and statistical modeling and interpretation to achieve biologically and clinically significant results.
Prof. Robert Powers' research group website and bio: https://chem.unl.edu/robert-powers
Nanoparticle-assisted NMR relaxation in protein dynamics & metabolomics
The 18th session of the Global NMR Discussion Meeting was held on 10th November 2020 via Zoom. Dr. Mouzhe Xie gave a talk on nanoparticle-assisted nuclear magnetic resonance (NMR) relaxation in protein dynamics and metabolomics. The video was recorded live during the presentation and serves as an educative lecture.
Bio: Mouzhe Xie studied chemical biology at Xiamen University (China) from 2009-2013. He received his Ph.D. degree from The Ohio State University (USA) in 2018, where he developed and applied solution NMR spectroscopy to study protein dynamics and metabolomics. He then spent 5 months at EPFL (Switzerland) as a visiting scientist. Currently, he is conducting postdoctoral research on nanoscale NMR and quantum sensing at the University of Chicago (USA).
Personal website: https://sites.google.com/view/xiemouzhe
Google scholar: https://scholar.google.com/citations?...
LinkedIn: https://www.linkedin.com/in/mouzhe-xi...
Abstract: In nanoparticle-assisted solution NMR, synthetic nanoparticles are added to NMR samples, which reduce the reorientational motion of molecules or protein regions in a selective or differential way. This leads to interesting spectral observations that contain critical information about the physicochemical properties, structures, dynamics, and functions of biomolecules. In this tutorial, I will introduce the basics of NMR relaxation theories, followed by some technical details including pulse selection and data processing. The discussion will be buttressed by recent studies on some important topics, such as supra-τc (slow) internal motions of globular proteins, cooperative binding of intrinsically disordered proteins to inorganic surfaces, and accurate metabolite identification in the context of NMR-based metabolomics."