Optimal control and its application in solid-state NMR

In session 26 held on 27th April 2021, Dr. Jan Blahut gave a talk on "Optimal control and its application in solid-state Nuclear Magnetic Resonance (NMR) spectroscopy", via Zoom. The video was recorded live during the presentation and serves as an educative lecture.

Optimal-NMR webpage: https://optimal-nmr.net

Bio:

Dr. Jan Blahut

2008-2013 M.S. in Organic Chemistry, Charles University in Prague

2013-2018 Ph.D. in Inorganic Chemistry, group of prof. P. Hermann, Charles University in Prague

2018-2020 Postdoctoral position in the group of prof. G. Pintacuda, High-filed NMR centre Lyon

2020-present: Postdoctoral position in the group of Dr. Zdenek Tosner, Charles University in Prague

Publons profile: https://publons.com/researcher/216308...

Abstract: Optimal control has its origins in economy and engineering as a mathematical tool to maximize profit or minimize disposed energy. Magnetic resonance is well suited for optimal-control application to design new pulse sequences with improved properties. We will focus on application in solid-state NMR, where the combination of sample spinning, powder averaging, dense network of involved interactions and RF field inhomogeneity render analytical approaches based on Average Hamiltonian Theory unfeasible. Despite the complexity of the problem, the practical application of optimal control based techniques is straightforward. It this tutorial we will also demonstrate how they can be implemented to your work-flow in a simple copy-paste manner, replacing traditional recoupling techniques.

Link: https://youtu.be/f6Qf6-SQSno

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Methyl Sidechain Probes for Solution NMR of Large Proteins