Videos
Gradient Pulses On Moving Spins
During the 86th session of the Global NMR Discussion Meetings held on May 21st, 2024 via Zoom, Dr. Jean Nicolas Dumez from the University of Nantes, France gave a talk on the topic "Gradient pulses on moving spins: flow NMR methods for reaction monitoring". The recording serves as a tutorial.
Abstract: Flow NMR is a powerful approach to monitor chemical reactions, with applications in fields such as catalysis and polymer science. The sample flow makes it necessary to revisit some of the core concepts of NMR pulse sequences. This presentation will describe recent developments of fast multidimensional NMR methods that are applicable in continuous flow, and the underlying spin dynamics concepts.
Dr. Dumez's research: https://www.univ-nantes.fr/jean-nicolas-dumez
Long-loved nuclear singlet spin order and its applications
During the 84th session of the Global NMR Discussion Meetings held on April 30th, 2024 via Zoom, Prof. Giuseppe Pileio from the University of Southampton, UK gave a talk on the topic "Long-loved nuclear singlet spin order and its applications". The recording serves as a tutorial.
Abstract: Nuclear singlet spin order is the population difference between the singlet and triplet states in a system of two coupled spin-1/2 nuclei. This form of order is long-lived, silent and accessible on demand. For almost two decades, my research activities were focused at exploiting these three main properties of nuclear spin order to develop new applications in NMR and MRI. In this talk, I will introduce the concept and the main features of singlet order as well as the tools developed for its manipulations. I will then show how we are using this form of order to enhance several NMR and MRI techniques for the long-term storage of hyperpolarisation, to obtain a new form of contrast in MRI, for the measurements of slow diffusion and flow, or for the determination of structural features of porous media such as tortuosity and structural anisotropy through singlet-assisted diffusion NMR.
Prof. Pileio's research: https://generic.wordpress.soton.ac.uk/gpgroup/
Hyperpolarized Xe NMR in Molecular Cavities Study and MR Imaging
During the 83rd session of the Global NMR Discussion Meetings held on March 26th, 2024 via Zoom, Prof. Leif Schröder from the German Cancer Research Center gave a talk on the topic "Hyperpolarized Xenon NMR for Exploring Molecular Host Cavities and Advancing MR Imaging". The recording serves as a tutorial.
Abstract: The large chemical shift range of Xe-129 NMR makes this nucleus a valuable probe in spectroscopy and biomedical imaging. Hyperpolarized Xe can be used also as dissolved noble gas to provide 10’000-fold improved sensitivity over extended periods of time. In combination with saturation transfer techniques, reversibly bound hyperpolarized xenon gives insights into exchange kinetics of various host-guest complexes. This talk will give an overview of studies investigating the affinity of dissolved Xe for various hosts like biogenic hollow protein structures with attoliter volumes or synthetic hosts for trapping individual Xe atoms. Both strategies find applications in the spectroscopic investigation of exchange kinetics of host-guest systems and in the design of ultra-sensitive magnetic resonance imaging agents.
Prof. Schroeder's research: https://www.dkfz.de/en/translationale-molekulare-bildgebung/index.php
Why Is DOSY So Different From COSY?
During the 80th session of the Global NMR Discussion Meetings held on February 13th, 2024 via Zoom, Prof. Gareth Morris from the University of Manchester, United Kingdom, gave a talk on the topic "Why is DOSY so different from COSY?". The recording serves as a tutorial.
Abstract:
Peaks in COSY, NOESY, ROESY and HSQC 2D spectra either appear where they should, or not at all. In DOSY spectra, it is all too common to see peaks at incorrect positions in the diffusion domain. This tutorial will explore why this happens, what we can do about it, and how to avoid being misled by DOSY spectra.
Prof. Gareth Morris' research group website and bio: https://nmr.chemistry.manchester.ac.uk/?q=node%2F13
Characterization of polymeric materials in bioapplications
During the 79th session of the Global NMR Discussion Meetings held on January 30th, 2024, via Zoom, Prof. Ann-Christin Pöppler from the University of Würzburg, Germany, gave a talk on the topic "Challenges in the characterization of polymeric materials for drug delivery and tissue engineering applications". The recording serves as a tutorial.
Abstract:
NMR spectroscopy is sensitive to subtle changes in local environment and dynamics over multiple length and time scales making it a versatile technique to study polymeric materials and incorporated molecules. Challenges, which will be discussed in this presentation arise from the size (distribution), rigidity and intrinsic disorder of the samples.
Prof. Ann-Christin Pöppler's research group website: https://www.chemie.uni-wuerzburg.de/oc/poeppler-group/
Inside an NMR Spectrometer
During the 73rd session of the Global NMR Discussion Meetings held on October 24th, 2023 via Zoom, Prof. Kazuyuki Takeda from Kyoto University in Japan, gave a talk on the topic "Inside an NMR Spectrometer". The recording serves as a tutorial.
Abstract: Let us take a brief look at what is happening inside an NMR spectrometer when we operate it, running pulse sequences and acquiring NMR signals. In particular, I will focus on open-resource, home-built NMR spectrometers we routinely use in our lab, and show how we apply them in the conventional and unconventional NMR experiments.
Website: http://kuchem.kyoto-u.ac.jp/bun/indiv/takezo/index_en.html http://www.kuchem.kyoto-u.ac.jp/organization/member/bk_200710/takezo_e.html
NMR Pulse Sequence Basics and Design Principles
During the 71st session of the Global NMR Discussion Meetings held on September 26th, 2023 via Zoom, Prof. Tairan Yuwen gave a talk on the topic "NMR pulse sequence basics and design principles". The recording serves as a tutorial.
Prof. Tairan Yuwen is an Assistant Professor at Peking University, China
Abstract: NMR is commonly used for studying structure and dynamics of molecules, and many NMR experiments have been developed for different purposes. In each NMR experiment it is necessary to choose the most suitable NMR pulse sequence to obtain optimal results, which requires understanding about the basic theory. During NMR pulse sequence the studied system is evolved under different types of interactions, which can be represented by density matrix or product operator. The basic syntax for NMR pulse sequence programming will be briefly introduced together with several examples, which helps to understand how NMR pulse sequences work and make further optimization.
Magnetic Resonance Spectroscopy Using Spin Defects in Diamond
During the 69th session of the Global NMR Discussion Meetings held on June 13th, 2023 via Zoom, Prof. Dominik Bucher gave a talk on the topic "Nano- and Microscale Magnetic Resonance Spectroscopy Using Spin Defects in Diamond". The recording serves as a tutorial.
Abstract: Nuclear magnetic resonance (NMR), one of the most powerful analytical techniques in chemistry and life sciences, is typically limited to macroscopic volumes due to its inherent low sensitivity. This excludes NMR spectroscopy from the analysis of microscopic sample sizes, such as in single-cell biology or microfluidic applications. In recent years, it has been shown that NMR signals from nano- to microscale volumes can be detected by a new class of sensors - quantum sensors based on defects in the diamond lattice - the nitrogen vacancy (NV) centre. In this talk, I will first introduce NV centres and explain how these atom-sized sensors can be used to detect NMR signals. In the second part, I will provide an overview of this rapidly developing technology and discuss potential applications ranging from surface and materials science to lab-on-a-chip applications.
Prof. Dominik Bucher is a Rudolf-Mößbauer Professor at the Technical University of Munich (TUM), Germany.
Website: https://www.ch.nat.tum.de/en/qsens/home/
Google scholar: https://scholar.google.de/citations?u...
Twitter: https://twitter.com/Bucherlab
NMR Studies of Gases Adsorbed in Materials and of CO2 Capture
During the 56th session of the Global NMR Discussion Meetings held on November 15th, 2022 via Zoom, Dr. Alexander Forse from University of Cambridge, gave a talk on the topic "A guide to NMR studies of gases adsorbed in materials, with examples on carbon dioxide capture". The recording serves as a tutorial.
Abstract:
In this zoominar I will introduce methods for carrying out NMR spectroscopy experiments on gas adsorption in porous materials. I will introduce the main approaches that are used for these experiments in the literature, and will give examples from our own research on carbon dioxide capture in metal-organic frameworks. Examples will include solid-state NMR studies of carbon dioxide capture in amine-functionalized MOFs, as well as pulsed-field gradient NMR measurements of anisotropic gas diffusion.
Speaker's biography:
2012-2015: PhD in Chemistry, University of Cambridge, UK (Prof. Grey)
2016-2019: Postdoctoral Fellow, UC Berkeley, USA (Prof. Reimer & Prof. Long)
2019-present: Assistant Professor, University of Cambridge, UK
Follow Dr. Forse's work here:
Twitter: https://twitter.com/alexforse1?lang=en
Google scholar: https://scholar.google.com/citations?...
Website: https://www.ch.cam.ac.uk/group/forse/
Electrophoretic NMR: an ion speedometer for concentrated electrolytes
During the 47th session of the Global NMR Discussion Meetings held on April 19, 2022 via Zoom, Dr. David Halat from UC Berkeley gave a talk on the topic "Electrophoretic NMR: an ion speedometer for concentrated electrolytes". The recording serves as a tutorial.
Abstract: Pulsed field gradient (PFG) NMR techniques are powerful probes of self-diffusion but remain insensitive to the charged nature of the mobile species. For example, Li-ion battery electrolyte performance is strongly affected by the drift velocity of the working (Li+) cation under an applied potential, and not necessarily to its diffusivity. By synchronizing PFG pulse programs with a simultaneous electric field, electrophoretic NMR (eNMR) can selectively measure cation, anion, and solvent motion and provide a full accounting of ion transport in concentrated electrolytes. I will discuss the experimental and practical underpinnings of eNMR, as well as its complementarity to MD simulations to reveal the migration of specific solvation structures.
Speaker's biography:
2009 — 2013: B.S. Mathematics and Chemistry, Montana State University, USA.
2013 — 2018: Ph.D., University of Cambridge, UK, (with Clare P. Grey)
2018 : Postdoc and FRS Research Associate, University of Cambridge, UK (with Clare P. Grey)
2018 — present: Postdoc, University of California Berkeley, USA (with Jeffrey A. Reimer and Nitash P. Balsara)
Google Scholar: https://scholar.google.com/citations?...
Twitter: @davidhalat